Detection of anti-F(ab')_2 antibody in patients with SLE and evaluation of its clinical significance / 中国免疫学杂志
Chinese Journal of Immunology
; (12)1985.
Article
in Zh
| WPRIM
| ID: wpr-535192
Responsible library:
WPRO
ABSTRACT
Anti-F(ab')_2 and anti-dsDNA-F(ab'):fragment(idiotype)Were prepared from digested normal human IgG and anti-dsDNA antibody with pepsin.Anti-F(ab')_2 antibody was determined by ELISA in 46 patients with SLE.A significant correlation between titers of anti-dsDNA-F(ab')_2 and anti-F(ab'):antibodies was observed.Results show high levels of anti-F(ab')_2 and low levels of anti-dsDNA antibodies in patients with remisson SLE activity.These findings suggest that the general IgG-F(ab')_2 antibodies and the anti-dsDNA-F(ab')_2 idiotypes in SLE sera may express some common structural epitopes.The measurement of anti-F(ab')_2 antibody levels may prove usefuladditional parameters assessing the clinical status.
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
1985
Type:
Article