Therapy of murine gastric cancer by 5-FC/CD suicide gene system combined with HSP-PC tumor vaccine / 中国癌症杂志
China Oncology
; (12)1998.
Article
in Zh
| WPRIM
| ID: wpr-536606
Responsible library:
WPRO
ABSTRACT
Purpose:
To investigate the antitumor effect of 5-fluorocytosine/cytosine deaminase (5FC/CD) suicide gene system combined with heat shock protein 70 peptide complexes(HSP70-PC) tumor vaccine.Methods:
5-FC was administrated intraperitoneally after recombinant adenoviruses carrying E.coli CD gene were injected into murine tumor tissue. At the same time,mice bearing tumor were inoculated s.c. with HSP70-PC.Results:
The combined therapy led to reduction in tumor growth, and complete tumor regression was observed in 70% of the mice. After the combined therapy, the tumor tissue showed more CD + 4 and CD + 8T cells infiltration, and the murine CTL activities increased significantly.Conclusions:
The therapy combining 5-FC/CD system with HSP-PC tumor vaccine is very effective in murine gastric cancer, and has potential for clinical usage.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
China Oncology
Year:
1998
Type:
Article