Quantitative analysis of histological components in prostatic transition zone / 中华泌尿外科杂志

ABSTRACT

Objective To analyze quantitatively the histological components, and to observe the morphological changes of the transition zone in benign hyperplastic prostates (BPH) and adult normal prostates. Methods The quantitative morphometry of 40 BPH specimens obtained from suprapubic transvesical prostatectomy and 10 normal prostatic specimens (controls) were performed with computer-assisted image analysis system,and all the samples were stained with hematoxylin and eosin (HE) and the Masson trichrome.The area percentages of stromal (smooth muscle and connective tissue),glandular epithelial and luminal components,the average areas of acini,lumens and epithelia,and the heights of epithelial cells were quantitated,respectively. Results ①The mean area percentages of different components between control group and BPH group were as follows smooth muscles,(23.83?8.53)% vs (35.35?8.33)% ( P 0.05);epithelia,(26.26? 7.45)% vs (17.76?4.61)% (P0.05).②The average areas of acini, epithelia and lumens of control group and BPH group were ( 0.087?0.028)mm 2 vs (0.062?0.030)mm 2 (P