The coexistence of estrogen receptor and interleukin-6 in the intra-cardiac ganglia of rats / 中国免疫学杂志

ABSTRACT

Objective:To investigate the expression of estrogen receptor(ER) and interleukin-6(IL-6) in the intra-cardiac ganglia of rats and to identify the coexistence of these two proteins in the intra-cardiac ganglia.Methods:The double labeling techniques of immunocytochemical staining were conducted in the study.Results:There were three immunoreactively-labeled neurons in the ganglia.The ER-staining was showed brown in color,locating in the nucleus;IL-6 staining was showed red in color,locating in the cytoplasm;there were ER/ IL-6 double-labeled cells in same section,which accounted for about 20% to 30 %of the total single and double labeled neurons.Conclusion:ER and IL-6 can coexist in same rat intra-cardiac ganglia cells.Therefore,it provides morphological evidence for the theory about immune-neuro-endocrine network at the cellular level.