Effects of Hypoxia on Calmodulin Levels of Lung Tissue and Intrapulmonary Arteriolar Wall in Young Pigs / 第三军医大学学报

ABSTRACT

The effects of chronic hypoxia on calmodulin levels of lung tissue and intrapulmonary arteriolar wall in young pigs were studied .The specimens of hypoxic animals were taken under hypoxic condition from the hypoxic animals. It was observed that (1) the swine exposed to chronic intermittent hypobaric hypoxia showed significant pulmonary prcssor response at 4000m simulated high altitude , (2) the calmodulin level of lung was higher in hypoxic group than in sea level one , while that of intrapulmonary arteriolar wall exhibited no significant difference between hypoxic and control groups . The latter finding suggests that hypoxic pulmonary arteriolar constriction may not be associated with an obvious change of calmodulin level in vascular smooth muscle .