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Potentiation Effect of Diazepam on ACTH Analgesia in the Mice / 第三军医大学学报
Journal of Third Military Medical University ; (24)1983.
Article in Chinese | WPRIM | ID: wpr-550025
ABSTRACT
Experimental methodssintraperitoneal injection of diazepam,r-aminobutyric acid (GABA) receptor antagonist (picrotoxin) and GABA synthesis inhibitor (iso-niazid) ;the pain threshold and serotonin ( 5 -HT) content in the brain are measured with spectrofluorometry.The effect of diazepam on ACTH analgesia (AA) is abstracted and the possible mechanisms of diazepam effect are studied.

Results:

diazepam increases the effect of AA.picroloxin and isoniazid reduce it and antagonize the analgesia effect of ACTH; diazepam increases the content of 5-HT in hipocampus,hypothalamus and midbrain;diazepam + ACTH increases,more than AC-TH or diazepam singly,the level of 5-HT in the 3 brain regions; picrotoxin and isoniazid reverse the effect of diazepam and ACTH on the content of 5-HT in the 3 brainsites; potentiation of diazepam on AA is antagonized by naloxone and atropine.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Third Military Medical University Year: 1983 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Third Military Medical University Year: 1983 Type: Article