The studies on pharmacokinetics of Quercetin in rabbits / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1986.
Article
in Zh
| WPRIM
| ID: wpr-550968
Responsible library:
WPRO
ABSTRACT
The studies on pharmacoki-netics of Quercetin in rabbits were carried out by UV-spectrophotometry. The experimental results were shown that after 10mg ? kg-1 of Quercetin iv administration in rabbits, the curve of plasma concentration - time was shown to fit an open two compartment model. The pharmacokinetic parameters were as followT1/2 (?) = 2. 91 ? 1. 36min,T1/2(?) = 183. 78?82. 67min,Vd=0. 624?0. 225L ???kg-1,CL = 3. 15 ?2. llml ? kg-1 ? min-1. The bioavailability (F) of Quercetin after 10mg ? kg-1 ig in rabbits was 42.7% and Cpk was 10. 9mg ? L, tpk was 60min.After 10mg ? kg-1 iv administration in rabbits,Quercetin was rapidly eliminated from the blood. The compound and its metabolites were exereten by kidney and bile.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article