Effects of LFN-? and IL-4 on MW-l? production in lupus nephritis / 中华肾脏病杂志
Chinese Journal of Nephrology
; (12)1997.
Article
in Zh
| WPRIM
| ID: wpr-552575
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effects of IFN-? and IL-4 on MIP- ? production of peripheral blood mononuclear cells (PBMC) in lupus nephritis (LN) Methods MIP-1? expression in supematants was determined by Elisa and MLP-l? mRNA in PBMC was detected by RT-PCR. Results (1) IFN-? increased MIP-1? prouduction of PBMC in LN. (2) IL-4 inhibited MIP-1? production of PBMC in LN. (3) No significant effect on PBMC in controls was found by either IFN-? or IL-4. Conclusion IFN-? enhances MLP- 1? production of PBMC in LN wherease LL-4 inhibits it.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Nephrology
Year:
1997
Type:
Article