EXPRESSIONS OF SIALYL LEWIS X AND P16 IN COLORECTAL CARCINOMA AND THEIR RELATIONSHIPS WITH MALIGNANT PROCLIVITY / 解放军医学杂志

ABSTRACT

This study was conducted to study the expressions of sialyl Lewis X and P16 protein in colorectal carcinoma and their relationship with differentiation, metastasis and prognosis of colo rectal carcinoma. Sialyl Lewis X and P16 expressions were determined with microwave-LSAB immunohistochemical technique. The positive rates of sialyl Lewis X and P16 were 92.2% and 42.2% respectively. The increased expression of sialyl Lewis X and the weakened expression of P16 were significantly correlated with metastatic proclivity and poor prognosis of the malignancy. These findings indicated that combined examination of the expression of sialyl Lewis X and P16 might be useful in estimating the differentiation, infitrtion, metastasis of colo-rectal carcinoma and prognosis of the patients.\;