Effect of propofol on amino acid levels in cultured pc12 cells impaired by n-methyl-d-aspartate / 解放军医学杂志
Article
in Zh
| WPRIM
| ID: wpr-559097
Responsible library:
WPRO
ABSTRACT
Objective To observe the influence of propofol on amino acid levels in cultured PC12 cells impaired by N-methyl-D-aspartate, and explore the possible protective action mechanism of anesthetic propofol. Methods The levels of amino acid were measured by high performance liquid chromatography (HPLC). Results After exposing to NMDA 300?mol/L for 4h, the release of glutamate levels from PC12 cells was increased significantly, whereas the release of glutamine, aspartate, and glysine levels remained unchanged. In the presence of propofol 12.5, 125?mol/L for 4h, the levels of glutamate decreased significantly (P
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Index:
WPRIM
Language:
Zh
Journal:
Medical Journal of Chinese People's Liberation Army
Year:
1981
Type:
Article