Effect of IGF-1 on the InsR?、? gene expression and protein content in pyaemia rats / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6)2004.
Article
in Chinese
| WPRIM
| ID: wpr-559844
ABSTRACT
Objective:
To investigate the influences of IGF-1 on the stress homone,InsR?、? gene expression and protein content in pyaemia rats.Methods:
SD rats with abdominal infection models established by cecal ligation and perforation method were randomly divided into three groups pyaemic group(n=10),parenteral nutrition group(PN group,n=10) and IGF-1 Group (n=10),and 10 SD rats were used as normal group(n=10).On the sixth day,Vena Cava blood was sampled to determine the level of glucose,insulin,glucagon,and IGF-1.In addition,the expression of the InsR?、? in liver and muscle were detected by immunohistochemistry and Real-Time PCR methods.Results:
The plasma glucose,insulin,glucagon in the IGF-1 group were significantly lower than that of the pyaemic group and PN group(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Parenteral & Enteral Nutrition
Year:
2004
Type:
Article
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