Comparison of hemodialysis in patients with aristolochic acid nephropathy in uremia stage and renal transplantation / 解放军医学杂志

ABSTRACT

Objective To investigate the incidence and clinical characteristics of urinary carcinoma in the patients with aristolochic acid nephropathy(AAN)in uremia stage who received maintenance hemodialysis or renal transplantation.Methods The data of 38 AAN patients who had received renal replacement therapy and treated in the authors' service from Mar.2000 to Dec.2006 were reviewed,and the incidence and clinical pathological features of urinary carcinoma in these 38 AAN patients were summarized,in order to look for correlation between the frequency of hemodialysis and the occurrence of carcinoma.Results 15 of the 38 AAN patients received hemodialysis,and the remaining 23 patients underwent renal transplantation.During the follow-up period,seven patients who received hemodialysis were reported to have developed urinary carcinoma,the incidence was 46.7%(7/15),which was significantly higher than the incidence in patients who had undergone renal transplantation(3/23,13.0%;P0.05).Conclusion The prevalence of urinary carcinoma was much lower in the AAN patients who had undergone successful renal transplantation than in those patients who received only maintenance hemodialysis.Renal transplantation may be of a better treatment for the AAN patients in uremia stage.There was no correlation between the frequency of hemodialysis and the incidence of carcinoma.