The effect of magnesium sulfate on apoptosis following traumatic brain injury (TBI)in rats / 重庆医科大学学报

ABSTRACT

Objective:To investigate apoptosis of neurone in rats following traumatic brain injury and the effects of magnesium sulfate on apoptosis of neurone after brain injury.Methods:Based upon the Feeney′s model the cellular apoptosis was observed in injuried cortex and hippocampus at the 2nd hour to the 5th day after medium traumatic brain injury by TUNEL technique.Results:1.The cellular apoptosis was observed in the injuried cerebral hemisphere at the 2nd hour after traumatic brain injury.The number of apoptotic cells reached its peak at the 2nd to the 3rd day after traumatic brain injury, then gradually reduced at the 5th day after traumatic brain injury.2.At the 8th hour to the 3rd day after treatment with magnesium sulfate,the number of the cellular apoptosis in the injuried cortex and hippocampus reduced significantly compared with the controls (P