Protective Effects of Total Flavone C on Myocardial Ischemia in Rats / 中药新药与临床药理

ABSTRACT

Objective To study the protective effects of total flavone C( TFC) on myocardial ischemia and to explore its mechanism.Methods Two kinds of models were established mouse model of myocardial ischemia induced by means of clampi ng trachea and rat models of myocardial ischemia induced by pititrin.Results TFC at the concentrations of 80 and 40 mg/kg markedly prolonged the cardioelectric time after clamping the trachea.TFC at the concentrations of 60 and 30 mg/kg can ameliorate the changes of ST and T wave in rat models,reduce the MDA contents in the myocardium and the serum of rats and decrease the activity of LDH in the serum of rats.Conclusion TFC has protective effects on moyocardial ischemia and its mechanism may be related with the inhibition of lipid peroxidation.