Effects of Stilbene-glycoside on Learning and Memory and Inflammatory Reaction of Brain in Dementia Mice / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)1993.
Article
in Chinese
| WPRIM
| ID: wpr-572496
ABSTRACT
Objective To observe the effect of 2,3,5,4'-tetrahydroxy stilbene-2-?-D-glycoside (TSG)on learning and memory and free radicals metabolism in mice with dementia induced by ?-amyloid(A?).Methods The mice models were established by injection of A?1-40 into the right lateral ventricle,and the treatment group was administered with TSG for 8 weeks by gastrogavage.Morris water maze and step-through test were performed in all the mice and then the mice were killed and radioimmunoassay was used to detect the content of interleukin-6(IL-6).Results The learning and memory in model mice were worse and the cortical IL-6 content increased compared to the normal control mice.TSG improved the learning and memory of A?-induced model mice and reduced cortical IL-6 content.Conclusion TSG could improve the learning and memory of dementia mice and decrease cortical IL-6 content,indicating a promising prospect in the treatment of dementia disease such as Alzheimer's disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
1993
Type:
Article
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