Protein Folding Study Based on The HNP Model and The Relative Entropy Approach / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-586651
ABSTRACT
Twenty kinds of amino acids are simplified into 3 types hydrophobic amino acids (H), hydrophilic amino acids (P) and neutral amino acids (N). Each residue is reduced to a bead which locates in the position of the C?琢 atom. The off-lattice model is adopted and the relative entropy is used as a minimization function to predict the tertiary structure of a protein. A new contact intensity function is given to consist with protein design research based on the relative entropy. Testing on several real proteins from Protein Data Bank (PDB) shows the good results obtained with the model and method. The root mean square deviations (RMSD) of the predicted structures relative to the native structures range from 0.30 to 0.70 nm. A foundation for studying protein design using the HNP model and the relative entropy was made.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Progress in Biochemistry and Biophysics
Year:
2006
Type:
Article
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