The localization and expression pattern of nuclear receptor NR4A1 protein in rat ovary / 医学研究生学报

ABSTRACT

Objective:To investigate the localization and expression pattern of nuclear receptor NR4A1 protein in follicle and corpus luteum cells at different estrous stages in cycling female SD rat. Methods:The SD experimental rats were divided into four ovarian stages based on the vaginal lavages,from which the ovaries were obtained in every cycling stage.The localization and expression pattern of NR4A1 in rat ovaries were characterized by immunohistochemistry. Results:NR4A1 was mainly expressed in the cytosol of ovarian theca cells and lutein cells.Expression level of NR4A1 in theca cell of mature follicle was significantly higher than that in the growing follicle(P