Expression of interleukin-6 in ischemic cerebrovascular disease / 中国组织工程研究

ABSTRACT

OBJECTIVE: To comprehensively analyze the relationship between interleukin-6 (IL-6) and ischemic cerebrovascular disease. DATA SOURCES A computer-based search was conducted in Pubmed for literatures related to the expression, effect, and significance of IL-6 in ischemic cerebrovascular disease pblished between January 1994 and March 2006 with the of "interleukin-6, Ischemia Cerebrovascular Disease; Interleukin-6, Ichemia Stroke", and the language was limited to English. STUDY SELECTION Retrieved data were arranged, and articles with strong aim were selected. Literatures published recently and those published in authorized journals of the same region were superior. DATA EXTRACTION A total of 122 relevant articles were retrieved, and 23 of them were in accordance with the inclusion criteria. DATA SYNTHESIS: IL-6 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory effects. It highly expresses in the cerebral tissue, cerebrospinal fluid and peripheral blood serum after cerebral ischemia. IL-6 plays an important role in the pathophysicoloy and inflammatory response to the ischemia cerebrovascular disease of acute stage. CONCLUSION: IL-6 plays an important role in the pathophysicological mechanism and prognosis of ischemic cerebrovascular disease, which can be taken as a prediction index for evaluating the focus of infection and neurofutional defects.