Progress in the construction of tissue-engineered adipose tissue / 中国组织工程研究

ABSTRACT

BACKGROUND: The repair of soft tissue defect is disturbing plastic surgeons for a long period of time. Each strategy has its own limitation. Adipe authoritative journals were included. Repetitive articles and Meta analysis articles were excluded. Finally 34 articles werose tissue engineering technique provides a novel resolving approach. OBJECTIVE: To analyze the research status of adipose tissue engineering and their defects, and to prospect the possible application in clinic. RETRIEVAL STRATEGY: A computer-based online search of Medline was undertaken to identify articles about adipose tissue construction published in English from January 1991 to July 2007 with the keywords "fat, tissue engineering". Meanwhile, we searched Chinese Journal Full-text Database for the Chinese articles dated from January 1991 to July 2007 with the same keywords in Chinese. 241 English and 101 Chinese articles were collected. The titles and abstracts were firstly read to select the articles about the construction of tissue-engineered adipose tissue, and 276 repetitive studies were excluded. LITERATURE EVALUATION: Sixty-six Chinese and English articles were selected for further analysis, and finally 30 articles were included. DATA SYNTHESIS: Cell types, scaffold, blood supply and microenvironment are factors for constructing tissue-engineered fat. Adipose tissue defect and insufficiency are two obstacles for the plastic surgeons for a long time. Autologous free fat transplantation is a common therapy, but its resorption limits the further application. Tissue engineering is a possible technique to resolve this problem. At present, the tissue-engineered construction of adipose tissue has become a study focus due to the great demand of plastic surgery. CONCLUSION: Graft remaining normal appearance and function for a long period of time can realize the application of tissue-engineered adipose tissue in clinic. Tissue-engineered adipose tissue is promising to resolve the problems like soft tissue defects in clinic.