The significance of anti-endothelial cell antibody AECA in Behcet's disease / 中华风湿病学杂志

ABSTRACT

Objective To evaluate the significance of anti-endothelial cell antibody (AECA) and the correlation between AECA and clinical features of Behcet's disease (BD). Methods AECA was detected in 73 BD, 60 SLE, 35 SSc, 30 RA, 62 systemic vasculitis patients and 40 health controls by indirect immunofluorescence analysis in which the endothelial cells from umbilical vein were used as the substrate. Results Higher frequency of AECA was found in BD (54.8%) with the specificity of 87.2%, compared to those in SLE (8%), SSc (9%), RA (10%), systemic vasculitis (27%) and healthy controls (2%, P<O.O1, respectively). However, the prevalence of ANA, other common auto-antibodies, hypocomplementemia, throm- bopenia and proteinuria were significantly lower in BD when compared with those with other autoimmune diseases (P<0.01). In addition, AECA- positive BD patients had significantly higher ESR than those with negative AECA (P<0.01). Conclusion AECA is one of the major parameters for the diagnosis of BD with high sensitivity and specificity.