Use of interphase fluorescence in situ hybridization for diction of trisomy 8 in hematologic disorders / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 98-99,104, 2008.
Article
in Zh
| WPRIM
| ID: wpr-601672
Responsible library:
WPRO
ABSTRACT
Objective To explore the value of interphase fluorescence in situ hybridization(FISH) in the detection of trisomy 8 in patients with hematologic disorders. Methods Seventy-seven patients were vestigated by directly labeled centrome DNA probes specific for 8 chromosome. The results were compared with that of conventional cytogenetic (CC) analysis. Results The proportion of trisomy 8 of 77 cases of hematologic disorders detected by FISH is higher than by G-banding karyotyping and FISH could offer the result when conventional cytogenetic methods failed to diagnose. Conclusion Interphase FISH is more sensitive in the detection of trisomy 8 than CC, and FISH displays its superiority in the detection of small clone.
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WPRIM
Language:
Zh
Journal:
Journal of Leukemia & Lymphoma
Year:
2008
Type:
Article