Diagnostic value of combined detection of various tumor markers in malignant hydrothorax and hydroperitoneum / 国际检验医学杂志

ABSTRACT

Objective To explore Diagnostic value of combined detection of alpha fetoprotein(AFP) ,carcino‐embryonic antigen (CEA) ,carbohydrate antigen 125(CA125) ,neurone specific enolase(NSE) and carbohydrate antigen 724(CA724) in malignant hy‐drothorax and hydroperitoneum .Methods According to the pathological diagnosis as gold standard ,receiver operating characteristic (ROC) curve was used to analyzed the cut‐off value for the diagnosis of malignant hydrothorax and hydroperitoneum in 291 pa‐tients ,and 135 patients with benign malignant hydrothorax and hydroperitoneum were enrolled as controls .Diagnostic value of sin‐gle and combined detection of tumor markers was analyzed .Results Area under the ROC curve of CEA and CA724 were higher than 0 .7 ,indicating that CEA and CA724 were with high diagnostic value .Among CEA ,CA724 ,NSE and CA125 ,used for single detection ,CEA was with high sensitivity(81 .7% ) ,Jorden index(0 .64) ,negative predictive value(67 .7% ) ,positive predictive value (90 .8% ) ,and NSE(82 .9% ) was with high specificity .Combined detection of tumor markers could increase diagnostic sensitivity , Jorden index and negative predictive value .Conclusion CEA could be with high diagnostic value of malignant hydrothorax and hydro‐peritoneum .Combined detection of tumor markers could increase diagnostic sensitivity ,Jorden index and negative predictive value .