Tuftsin can attenuates symptoms in experimental autoimmune encephalo-myelitis mouse / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 323-326,331, 2016.
Article
in Zh
| WPRIM
| ID: wpr-603528
Responsible library:
WPRO
ABSTRACT
Objective:
To explore whether Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses.Methods:
C57BL/6 mice were immunized with MOG35-55 peptides,and evaluated for clinical neurological score every day .10 mice of the EAE were injected with Tuftsin subcutaneously .The spinal cord were stained by the methods of Haematoxylin Eosinstain , Luxol Fast Blue stain.The mRNA expression of IL-10 and TNF-αfrom brian tissue were detected at the 28 days by RT-PC method.Results:
The controlled mice had no symptoms of disease and HE ,LFB were normal.Comparison EAE group with Tuftsin group of HE,LFB,EAE group were server than Tuftsin group.The expression of IL-10 in Tuftsin group was higher than EAE group.The expression of TNF-αin Tuftsin group was lower than EAE group .Conclusion:
Tuftsin can attenuates symptoms in experimental autoimmune encephalomyelitis mouses .
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article