Effect of Rat Intestinal Bacteria on Metabolism of Pedunculoside in vitro / 中国药师
China Pharmacist
;
(12): 621-623,624, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-603815
ABSTRACT
Objective:
To study the metabolism of pedunculoside treated with rat intestinal bacteria in vitro.Methods:
Pedunculo-side and rat intestinal bacteria were incubated in vitro for 0, 4, 8, 24 and 48 hours under anaerobic condition. After extracted repeat-edly by ethyl acetate, the metabolites in the incubation media were qualitatively and quantitatively analyzed by HPLC.Results:
Totally 90. 8% of pedunculoside was transformed to M2 after incubated with rat intestinal bacteria in vitro for 48 hours, and a detailed compari-son of HPLC profiles between M2 and rotundic acid showed M2 was rotundic acid.Conclusion:
Pedunculoside can be metabolized to rotundic acid by rat intestinal bacteria in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2016
Type:
Article
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