Content Determination of Aciclovir Cream by Centrifugal Partition Chromatography / 中国药房
China Pharmacy
;
(12): 2567-2568,2569, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-605112
ABSTRACT
OBJECTIVE:
To establish a method for the content determination of Aciclovir cream.METHODS:
Centrifugal parti-tion chromatography(CPC)was conducted. The solvent system was hexane-acetonitrile-water(2∶1∶1,V/V/V),the injection vehicle was an aqueous solution of 5%Tween 80 and the volume was 1.0 ml;the flow rate was 5 ml/min;the wavelength was 254 nm. RE-SULTSThere was a good linear relationship between quality concentration and peak area in the range of 0.012 7-0.126 7 mg/ml (r=0.998 7). The RSD of precision,stability and reproducibility tests was all no more than 2.0% and the average recovery was 97.34%(RSD=0.90%,n=9).CONCLUSIONS:
The method is with high precision and accuracy,and can be used for the content determination of principal components of Aciclovir cream.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2015
Type:
Article
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