Pharmacokinetic Study of Puerain Solid Self-microemulsion Capsules in Rats in vivo / 中国药房
China Pharmacy
; (12): 4773-4774,4775, 2015.
Article
in Zh
| WPRIM
| ID: wpr-605382
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To study the pharmacokinetic characteristics of Puerarin solid self-microemulsion capsules in rats in vi-vo.METHODS:
The rats were randomly divided into two groups with 18 rats in each group. They were given Puerarin solid self-mi-croemulsion capsules(S-SMEDDS capsules)and commercially available Yufeng ningxin tablet,with the dose of 158.15 mg/kg puer-arin. The 0.2 ml blood samples were collected from tail vein 0,5,10,20,40,60,90,120,180,240,360,480,600 min after medication,respectively. The blood concentration of puerarin was determined by HPLC,and pharmacokinetic parameters and rela-tive bioavailability were calculated by using 3p87 software.RESULTS:
The metabolism of puerarin was one-compartment model in rats. Pharmacokinetic parameters of S-SMEDDS capsules and Yufeng ningxin tablet were as follows as cmax of (1.032 0 ± 0.020 6) and(0.587 3±0.011 7)μg/ml,t1/2ke of(116.431 4±2.166 0)and(88.222 6±1.752 4)min,AUC0-t of(261.532 2±1.464 0)and (102.835 5±1.957 4)μg·min/ml. Relative bioavailability was 238.77%.CONCLUSIONS:
Compared with Yufeng ningxin tablet, S-SMEDDS capsules are absorbed more completely and removed faster.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
China Pharmacy
Year:
2015
Type:
Article