Impact of Renal Function Injury on the Diagnostic Value of NT-proBNP in Patients With Heart Failure / 中国循环杂志

ABSTRACT

Objective: To explore the impact of renal function injury on diagnostic value of NT-proBNP in patients with heart failure (HF). Methods: A total of 420 patients with cardiovascular disease at (50-75) years of age were divided into 2 groups based on left ventricular ejection fraction (LVEF): Control group, the patients with normal cardiac function, LVEF≥40%,n=232 and HF group, LVEFeGFR≥60 ml/min·1.73m2), Moderate renal injury (60>eGFR≥30 ml/min·1.73m2) and Severe renal injury (eGFR Results: Compared with Control group, HF group had increased blood level of NT-proBNP,P0.05, while it was much higher in Moderate and Severe renal injury subgroups than Normal renal function subgroup,P Conclusion: Moderate to severe renal function injury could increase circulating level of NT-proBNP and therefore, the cut-off value of NT-proBNP for HF diagnosis should be elevated accordingly in patients of HF combing renal injury.