Application of autologous platelet-rich plasma in spinal surgeries / 中国组织工程研究

ABSTRACT

BACKGROUND: Autologous platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein derived from autologous whole blood. The activated platelets can release a large number of high concentrations of growth factors and bioactive substances, which provides a theoretical basis for its application in various disciplines and fields. At the same time, autologous PRP has been popularized because it will not cause immune rejection with extensive sources, easy to extract and low cost.OBJECTIVE: To summarize the preparation method and performance of autologous PRP, and to explore its latest research results and underlying mechanisms in spinal surgeries.METHODS: A computer-based online retrieval of CNKI and PubMed databases was performed for articles concerning autologous PRP used in spinal surgeries. Finally, 42 eligible literatures were included according to the inclusion and exclusion criteria.RESULTS AND CONCLUSION: (1) Autologous PRP is rich in a variety of growth factors and bioactive substances, so it has been used in the fields of disc repair, bone conduction and osteoinduction, and its effectiveness has been confirmed through abundant basic and clinical trials. (2) Meanwhile, autologous PRP also is used for tissue repair and skin regeneration, such as spontaneous cerebrospinal fluid leakage and pressure ulcer. (3) Notably, autologous PRP has shown a promising prospect in the field of spinal surgeries.