Retrospective Observation of the Clinical Efficacy of Mouse Nerve Growth Factor in the Treatment of Unilateral Sudden Deafness / 听力学及言语疾病杂志

ABSTRACT

Objective To investigate the clinical efficacy of nerve growth factors in the treatment of sudden deafness.Methods A retrospective analysis was performed on 124 cases of hospitalized patients who suffered from unilateral sudden deafness from November 2013 to February 2015.The patients were divided into two groups 59 in the treatment group and 65 in the control group.Each group was further divided into four subgroups according to different audiometric curves the low-frequency declining type, the high-frequency declining type, the flat type, the completely deafness type.The control group the patients were treated with the conventional therapy according to different audiometric curves.The treatment group intramuscular mouse nerve growth factor treatment was added on the basis of conventional therapy mentioned above.The both treatments lasted 10 days.The total efficiency of two groups was compared ,and the efficiency of the subgroups was also compared.Results The total efficiency of the treatment group was 64.40% and 44.62% for the control group.The total efficiency of the treatment group was significantly higher than the control group.The analysis revealed as having statistically significant differences (x2=4.877,P=0.0320.05).Conclusion The mouse nerve growth factor has a positive effect on the treatment of sudden deafness, and has shown the acceptable clinical efficacy without side-effect.Thus the mouse nerve growth factor is a safe and effective drug for treating sudden deafness.