Clinicopathologic analysis of cerebral hemisphere ulegyria in 26 patients with refractory epilepsy / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
; (24): 784-787, 2017.
Article
in Zh
| WPRIM
| ID: wpr-610508
Responsible library:
WPRO
ABSTRACT
Objective To investigate the clinicopathologic features of cerebral hemisphere ulegyria in children with refractory epilepsy.Methods The clinical and pathologic findings were reviewed in 26 children who underwent resection of lesion and epileptogenic lobectomy operation in the Neurosurgery Department of Haidian Hospital,Haidian District of Peking University Third Hospital,from January 2011 to August 2015,and pathological diagnosis was cerebral hemisphere ulegyria.Results All children including 19 male and 7 female had medically intractable seizures.The mean ages of seizure onset and disease duration were 3.93 years old (from 10 days to 12 years old) and 5.42 years (from 1 month to 13 years),respectively.Eight cases had seizures because of perinatal period injury,and 12 cases developed seizures owing to infancy injury and others had no cause of disease.The mean operation age was 9.35 years old (5-14 years old).Fourteen cases underwent multilobar resection and the whole corpus callosum incision,and 12 cases were given modified anatomical cerebral hemisphere resection.The pathological diagnoses of brain tissues were cerebral hemisphere ulegyria with focal cortical dysplasia(FCD) Ⅲ d and dual pathology.Seizure outcome after the operation revealed that 19 cases (73.08%) had an Engel grade Ⅰ,3 cases (11.54%)had an Engel grade Ⅱ,2 cases (7.69%) had an Engel grade Ⅲ,and 2 cases (7.69%) missed the follow-up.Conclusions Acquired brain injury during the period of infant can cause ulegyria and cortical dysplasia,resulting in intractable epilepsy.The treatment of improved anatomical cerebral hemisphere resection and multilobar resection is significantly effective.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Applied Clinical Pediatrics
Year:
2017
Type:
Article