Relationship Between Serum mRNA Level of Heparin Binding Epidermal Growth Factor and Acute Coronary Syndrome Occurrence / 中国循环杂志
Chinese Circulation Journal
; (12): 748-751, 2017.
Article
in Zh
| WPRIM
| ID: wpr-614229
Responsible library:
WPRO
ABSTRACT
Objective:
To evaluate the relationship between serum mRNA level of heparin binding epidermal growth factor (HB-EGF) and acute coronary syndrome (ACS) occurrence.Methods:
Our research included in 2 groups ACS group,n=50 patients and Control group,n=100 normal subjects. Serum HB-EGF mRNA level was examined by RT-PCR and the relationship between HB-EGF mRNA and ACS occurrence was assessed by Logistic regression analysis.Results:
Compared with Control group, the serum HB-EGF mRNA level of ACS group was higher (0.22±0.73) vs (0.46±0.14),P<0.05. With adjusted meaningful factors of hypertension, smoking, TG, TC, LDL-C, HDL-C and BMI by single factor analysis, multi Logistic regression analysis indicated that serum HB-EGF mRNA was related to ACS occurrence (OR=5.813, 95% CI 2.342-14.426,P<0.001) which meant that upon 0.1 grey value of HB-EGF mRNA elevation, the risk of ACS occurrence may increase 4.813 folds accordingly.Conclusion:
Serum HB-EGF mRNA level was related to ACS occurrence.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Circulation Journal
Year:
2017
Type:
Article