The effects of nicardipine induced controlled hypotension in patients underwent orthognathic surgery: A systematic review and meta-analysis / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 503-509, 2017.
Article
in Zh
| WPRIM
| ID: wpr-614845
Responsible library:
WPRO
ABSTRACT
Objective:
To evaluate the clinical effects of nicardipine for induced controlled hypotension in patients underwent orthognathic surgery.Methods:
The related trails were searched from English and Chinese literature databases.The quality of the RCTs was evaluated by 2 indepandent reviewers.The data were statistical analyzed using the Rev Man 5.3.3 software.Results:
5 RCTs with 248 patients were included.Meta-analysis and descriptive analysis indicated that blood loss of nicardipine group was more than that of remifentanil group [WMD =43.85,95% CI(20.52,67.18)].There was no significant difference in blood loss between nicardipine group and dexmedetomidine group and nitroglycerin group.There was no significant difference in transfusion between nicardipine group and the control group.Nicardipine increased the heart rate during controlled hypotension and caused QT prolongation (P < 0.001).Nicardipine had no adverse effects on cerebral oxygen saturation and neurophysiological function.Urinary N-acetyl-1-b-D-glucosaminidase was lower in nicardipine group than that in remifentanil group (P < 0.05).Conclusion:
Nicaridpine is effective in the induced controlled hypotension during orthognathic surgery,with potential renal protective effect.However,it is not better than the remifentanil on reducing the blood loss.Nicardipine can increase the heart rate and prolong the QT interval during the controlled hypotension.
Full text:
1
Index:
WPRIM
Type of study:
Systematic_reviews
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2017
Type:
Article