A study of correlation of anti-Helicobacter pylori antibody and anti-aquaporin 4 antibody in centre neurological system demyelination disease / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1371-1374, 2017.
Article
in Zh
| WPRIM
| ID: wpr-615050
Responsible library:
WPRO
ABSTRACT
Objective:To investigate the relationship between anti-Helicobacter pylori antibody(Hp-IgG)and anti-aquaporin 4 antibody which are in neuromyelitis optica(NMO)and multiple sclerosis(MS).Methods: Serum specimens were collected from the 33 patients with MS,7 patients with NMO,and 35 health examination cases.Hp-IgG were detected by enzyme-linked immunosorbent assasy and anti-aquaporin 4 antibody were detected by cell based assay respectively.The positive rate of Hp-IgG and anti-aquaporin 4 antibody were analyzed,and the difference of Hp-IgG positive rate was compared between patients with Hp-IgG positive and negative.Results: Serum Hp-IgG positive rate of MS,NMO and normal control groups were 69.70%,85.71% and 42.86% respectively with a significant statistically difference of Hp-IgG(P0.05).Serum anti AQP4 antibody positive rate of MS,NMO and normal control groups were 4.2%,85.71% and 0% respectively with a significant statistically difference of anti AQP4 antibody(P0.05).Conclusion: HP infection is a risk factor for the occurrence of MS and NMO,but not associated with MS and NMO patients with anti AQP4 antibodies.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2017
Type:
Article