Application of ROC curve for evaluating risk evaluation value of serum LDH, BXTM, β2-MG,CRP and DD in bone marrow infiltration of non-Hodgkin's lymphoma / 重庆医学
Chongqing Medicine
; (36): 2486-2488,2491, 2017.
Article
in Zh
| WPRIM
| ID: wpr-620382
Responsible library:
WPRO
ABSTRACT
Objective To investigate the relationship between the indexes change of lactate dehydrogenase(LDH),serum tumor associated material(BXTM),β2-microglobulin(β2-MG),C-reactive protein(CRP) and D-dimer(DD) with lymphoma cell bone marrow infiltration(BMI) degree in the patients with non-Hodgkin's lymphoma(NHL).Methods Seventy-four cases of initially treated NHL were retrospectively analyzed and divided into the bone marrow invasion group(BMI,26 cases),lymphoma cell leukemia group(LMCL,31 cases) and non-BMI group(N-BMI,17 cases).The related indexes levels in each group were detected.ROC curve was drawn and analyzed.Results The levels of LDH,β2-MG,CRP and DD levels in the BMI group and LMCL group were higher than those in the N-BMI group(P<0.05).Based on the ROC curve analysis,the optimal diagnostic cut-off points of each index in BMI were determined.The CRP and LDH had good sensitivity(100.00 %),specificity(80.00 %-100.00 %) and diagnostic accuracy(80.00 % 100.00%).In the LMCL group,the diagnostic accuracy of DD,BXTM and β2-MG was 63.30 %-100.00%.Conclusion The changes of LDH,CRP,β2-MG and DD in the patients with NHL are consistent with the BMI severity of lymphoma cells,which has a good clinical value in staging,curative effect judgment and prognosis.
Full text:
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Index:
WPRIM
Type of study:
Etiology_studies
/
Prognostic_studies
Language:
Zh
Journal:
Chongqing Medicine
Year:
2017
Type:
Article