Effects of non-wounded leg ischemic post-conditioning on the level of TNF-α and NO in serum of rats undergoing pancreas transplantation / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
; (6): 18-20, 2011.
Article
in Zh
| WPRIM
| ID: wpr-622274
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WPRO
ABSTRACT
Objective To evaluate the effects of non-wounded leg ischemic post-conditioning on the serum TNF-α and NO level of rats undergoing pancreas transplantation. Methods Group Sham consisted of 6 normal SD rats. 12 diabetic SD rats were randomly assigned to 2 groups I/R group consisted of 6 diabetic rats which received ischemia reperfusion and NWLIPO group consisted of 6 diabetic rats which received ischemic post-conditioning. Blood glucose was measured before and after reperfusion. The level of serum NO and TNF-α was monitored 2 hours after long-time reperfusion. Results The level of blood glucose and TNF-α in NWLIPO group was lower than that in I/R group (P<0. 01) while the level of NO was higher in NWLIPO group than in I/R group (P<0.01). Conclusion Non-wounded leg ischemic post-conditioning can increase serum NO synthesis and down-regulate TNF-α.
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Endocrine Surgery
Year:
2011
Type:
Article