Dynamic Changes on Blood S-100 and Protein Expression of Brain in Newborn Rats with Bilirubin Encephalopathy / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)2006.
Article
in Zh
| WPRIM
| ID: wpr-639007
Responsible library:
WPRO
ABSTRACT
Objective To explore the changes of S-100 protein(S-100) levels in blood in newborn rats with bilirubin encephalopathy.Methods The model was established by administered bilirubin intraperitoneally(200 mg/kg) in newborn rats.The blood and brains samples were taken from 8 rats at the sequential time points of 6,12,24,48,72 and 96 h after the model established.Eight normal rats were used as the control.The dynamic changes of S-100 were detected by enzyme linked immunosorbent assay(ELISA) and immunohistochemical technique.Results S-100 significantly increased in blood of bilirubin encephalopathy newborn rats compared with controls(P
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WPRIM
Language:
Zh
Journal:
Journal of Applied Clinical Pediatrics
Year:
2006
Type:
Article