Genetic Research of Gene of Gamma 2 Subunit of Gamma-Aminobutyric Acid Type A Receptor in Pedigrees of Generalized Epilepsy with Febrile Seizures Plus / 实用儿科临床杂志

ABSTRACT

Objective To find the relationship between mutation of gamma 2 subunit of the gamma-aminobatyric acid type A receptor(GABRG2) and generalized epilepsy with febrile seizure plus(GEFS+).Methods Probands of 10 families with GEFS+ were selected,the GABRG2 gene were sequenced.Results We found a single nucleotide polymorphism site,and did not find the reported mutations.Conclusion GABRG2 mutation is not common in Hans of northern China.