Clinical Characteristics of Angiocentric Immunoproliferative Lesions in Head and Neck / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 1274-1278, 1999.
Article
in Ko
| WPRIM
| ID: wpr-646058
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
The histologic features of polymorphic reticulosis are identical to those of sinonasal "angiocentric immunoproliferative lesions" (AILs) which are characterized by angiocentric and angioinvasive lymphoid infiltrates with a wide range of cytologic atypia. 1) This report was conducted to further define the clinicopathological nature of this lesion and evaluate the important prognostic factors and therapeutic strategies. MATERIALS ANDMETHODS:
The clinical features and therapeutic outcomes of 22 patients with AILs were reviewed. Histologic grading was performed by using previously reported criteria (Grade I-III).2) To clarify the cell origin of AIL, immunohistochemical studies were performed in 21 cases.RESULTS:
On the slide review, 10 cases were Grade II and 12 cases were grade III which showed characteristic histologic features similar to those of peripheral T-cell lymphoma. On immunohistochemical studies, neoplastic cells of all patients had a T-cell phenotype. The difference in primary treatment results according to the histologic grade, clinical staging and therapeutic modalities was not significant statistically. The overall 5 year survival rates were 58%.CONCLUSION:
Our results suggest strongly that quite a significant portion of AIL may be in fact T-cell lymphoma. The only significant prognostic factor that predicts better survival is the achievement of initial complete response.Key words
Full text:
1
Index:
WPRIM
Main subject:
Phenotype
/
T-Lymphocytes
/
Granuloma, Lethal Midline
/
Survival Rate
/
Lymphoma, T-Cell
/
Lymphoma, T-Cell, Peripheral
/
Head
/
Neck
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
1999
Type:
Article