Biological Interaction Between Human Gingival Fibroblasts and Vascular Endothelial Cells for Angiogenesis: A Co-culture Perspective
Tissue Engineering and Regenerative Medicine
; (6): 495-505, 2017.
Article
in En
| WPRIM
| ID: wpr-646608
Responsible library:
WPRO
ABSTRACT
Advancement in cell culture protocols, multidisciplinary research approach, and the need of clinical implication to reconstruct damaged or diseased tissues has led to the establishment of three-dimensional (3D) test systems for regeneration and repair. Regenerative therapies, including dental tissue engineering, have been pursued as a new prospect to repair and rebuild the diseased/lost oral tissues. Interactions between the different cell types, growth factors, and extracellular matrix components involved in angiogenesis are vital in the mechanisms of new vessel formation for tissue regeneration. In vitro pre-vascularization is one of the leading scopes in the tissue-engineering field. Vascularization strategies that are associated with co-culture systems have proved that there is communication between different cell types with mutual beneficial effects in vascularization and tissue regeneration in two-dimensional or 3D cultures. Endothelial cells with different cell populations, including osteoblasts, smooth muscle cells, and fibroblasts in a co-culture have shown their ability to advocate pre-vascularization. In this review, a co-culture perspective of human gingival fibroblasts and vascular endothelial cells is discussed with the main focus on vascularization and future perspective of this model in regeneration and repair.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Osteoblasts
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Regeneration
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In Vitro Techniques
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Coculture Techniques
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Cell Culture Techniques
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Tissue Engineering
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Myocytes, Smooth Muscle
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Intercellular Signaling Peptides and Proteins
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Endothelial Cells
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Extracellular Matrix
Type of study:
Guideline
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Tissue Engineering and Regenerative Medicine
Year:
2017
Type:
Article