Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
The Korean Journal of Internal Medicine
; : 168-178, 2011.
Article
in En
| WPRIM
| ID: wpr-64777
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Increased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight sugarcane wax acids, has been shown to inhibit cholesterol synthesis prior to mevalonate production, resulting in a reduction of bone loss and resorption in ovariectomized rats. Moreover, previous studies have demonstrated that short-term D-003 treatment reduces urinary excretion of deoxypyridinoline/creatinine in postmenopausal women. METHODS: We performed a double-blinded, placebo-controlled study to investigate the effects of D-003 (10 mg/day) treatment for 3 years on bone mineral density (BMD) in 83 postmenopausal women with low BMD. RESULTS: Over 3 years, D-003 treatment increased lumbar spine BMD (5.1%, p < 0.01) and improved osteoporosis-related quality of life scores as compared with placebo-treated controls. D-003 was also well tolerated; the frequency of adverse events in the bone, joints, or muscle with D-003 treatment (p < 0.05) was lower than in the placebo group. CONCLUSIONS: D-003 treatment (10 mg/day) for 3 years increased lumbar spine BMD and produced clinical improvements in postmenopausal women with low BMD. Further studies, however, will be required to confirm these results.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Quality of Life
/
Time Factors
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Absorptiometry, Photon
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Bone Density
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Osteoporosis, Postmenopausal
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Double-Blind Method
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Surveys and Questionnaires
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Analysis of Variance
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Treatment Outcome
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Cuba
Type of study:
Clinical_trials
Limits:
Adult
/
Aged
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Female
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Humans
Country/Region as subject:
Caribe
/
Cuba
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2011
Type:
Article