Elevated Serotonin-immunoreactive Neurons in the Raphe Nucleus of the Ataxic Mutant Mouse, Pogo / 대한해부학회지
Korean Journal of Anatomy
; : 395-402, 2005.
Article
in Ko
| WPRIM
| ID: wpr-648772
Responsible library:
WPRO
ABSTRACT
This study was carried out to investigate the distribution of serotonin-immunoreactive neruons in the raphe nucleus of the ataxic pogo (pogo/pogo) mice derived from a Korean wild mice. Using by immunohistochemistry, we undertook to elucidate any correlation between the serotonin expression and behavior ataxia including abnormal hindlimb extension in the ataxic pogo mice. The present study has two important findings. First, serotonin immunoreactivity was increased in the raphe nucleus of the ataxic pogo mice. Second, serotonin immunoreactivity was different with the region of raphe nucleus. In the dorsal part of dorsal raphe nucleus (DRD), ventrolateral part of dorsal raphe nucleus (DRVL) and median raphe nucleus (MR), serotonin immunoreactivity was increased, whereas the ventral part of dorsal raphe nucleus (DRV) and interfascicular part of dorsal raphe nucleus (DRI) was similar with the control mice. Therefore, elevated expression of the serotonin in the raphe nucleus of ataxic pogo mice might be a source of behavior ataxia and may be related with the induction of the ataxic phenotype including abnormal hindlimb movements.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Phenotype
/
Ataxia
/
Raphe Nuclei
/
Immunohistochemistry
/
Serotonin
/
Hindlimb
/
Neurons
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Anatomy
Year:
2005
Type:
Article