Effects of Estrogen on Intracellular Calcium-Related T-Lymphocyte Function
Tissue Engineering and Regenerative Medicine
; (6): 270-273, 2016.
Article
in En
| WPRIM
| ID: wpr-649689
Responsible library:
WPRO
ABSTRACT
Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E₂) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E₂ concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E₂. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Gonadal Steroid Hormones
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B-Lymphocytes
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T-Lymphocytes
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Calcium Channels
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Calcium
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Cytokines
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Fura-2
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Tissue Engineering
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Regenerative Medicine
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Estradiol
Limits:
Humans
Language:
En
Journal:
Tissue Engineering and Regenerative Medicine
Year:
2016
Type:
Article