A Interventional Study in a Real Life Setting to Assess the Clinical Efficacy and Effect on Fracture in the 1 Year after Injection of Zoledronic Acid in Osteoporotic Patients with Long Bone or Spine, Pelvic Fractures / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
; : 320-326, 2016.
Article
in Ko
| WPRIM
| ID: wpr-651022
Responsible library:
WPRO
ABSTRACT
PURPOSE:
We studied the improvement of back pain in vertebral fracture and fracture healing in non-vertebral fracture after treatment with zoledronate in postmenopausal patients. MATERIALS ANDMETHODS:
Postmenopausal women with bone mineral density (BMD) T-score of -2.5 or less and existing vertebral fractures or non-vertebral fractures between January 2011 and June 2012 were included. Patients received a single intravenous infusion of zoledronate within 3 days after diagnosis of fractures. The primary outcome was BMD and secondary outcomes were visual analogue scale (VAS) for back pain, fracture healing, and new clinical fracture.RESULTS:
T-score increased significantly in the vertebral fracture group (n=97) and non-vertebral fracture group (n=31) at 1 year (p<0.05). The average VAS for back pain decreased significantly in the vertebral fracture group (p<0.05) and there was no delayed union, nonunion in the non-vertebral fracture group. There was no re-fracture and 3 new clinical fractures (2.34%) occurred during the follow-up period.CONCLUSION:
Zoledronate, as treatment in postmenopausal osteoporosis patients can improve BMD, reduce back pain in vertebral fracture, and has no negative effect on bone healing after fracture in non-vertebral fracture.Key words
Full text:
1
Index:
WPRIM
Main subject:
Osteoporosis
/
Spine
/
Infusions, Intravenous
/
Bone Density
/
Osteoporosis, Postmenopausal
/
Follow-Up Studies
/
Treatment Outcome
/
Fracture Healing
/
Back Pain
/
Diagnosis
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
Language:
Ko
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2016
Type:
Article