Morphological Changes of Cochlear Structures after Cisplatin Administration / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 538-543, 2002.
Article
in Ko
| WPRIM
| ID: wpr-651146
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Cisplatin is frequently used in the treatment of various forms of malignancies. It's therapeutic efficacy, however, is limited due to the occurrence of sensorineural hearing loss. Little is known about the course of hearing loss after cessation of cisplatin administration. We observed the cochlear duct morphology with normal and cisplatin treated animals. MATERIALS ANDMETHODS:
Healthy rats (strain Sprague-Dawly, weighting 80-100 mg) were used for all experiments. Total 15 rats were selected. They were divided into two groups, a treated group and a control. Four survival groups (n=3, respectively) were assigned as the treated group. After treatment with cisplatin, each survival group was sacrificed 1, 4, 10, 20 days. Except for the normal control (n=3), twelve animals were treated with cisplatin by daily I.P. injection of 1.5 mg/kg for 8 consecutive days.RESULTS:
One day after cessation of cisplatin administration, outer hair cells (OHCs) loss and stria vascularis were degenerated especially in the basal turn. At 4, 10, 20 days, the OHCs and stria vascularis morphology of the survival group were similar to those of the survival group at one day.CONCLUSION:
Our findings suggest cisplatin ototoxicity is predominantly involved in the basal turn of cochlear duct. This finding was significantly correlated with high frequency hearing loss of cisplatin ototoxicity.Key words
Full text:
1
Index:
WPRIM
Main subject:
Stria Vascularis
/
Cisplatin
/
Cochlear Duct
/
Hair
/
Hearing Loss
/
Hearing Loss, Sensorineural
Limits:
Animals
Language:
Ko
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2002
Type:
Article