Multiple Nonfunctioning Parathyroid Carcinoma Secondary to Chronic Renal Failure / 대한이비인후과학회지

ABSTRACT

Parathyroid carcinoma is a rare entity accounting for only 0.5% to 5% of all cases of parathyroid neoplasm. Most of these malignancies present themselves as functional hormone-producing masses with elevated serum levels of parathormone and calcium. These tumors may also be nonfunctional, which is even rarer. Clinical detection of nonfunctioning parathyroid carcinoma prior to operation is primarily based on symptoms of an expanding neck mass and voice change. These condition may allow it to escape clinical attention until it has achieved an advanced state. So, the prognosis is relatively too bad. Most of these tumors often arise from preexisting parathyroid hyperplasia or adenoma. En bloc resection of primary lesion, ipsilateral thyroid lobe and isthmus together with a neck dissection only in case of lymph node involvement is recommended as the standard treatment. In this paper, we will introduce a case report of a bilateral nonfunctioning parathyroid carcinoma secondary to chronic renal failure.