Study on the effectiveness and safety of intra-articular injection of tranexamic acid combined with drainage clamping 6 hour program on patients with perioperative blood loss of primary total knee replacement / 中国生化药物杂志

ABSTRACT

Objective To study the intra-articular injection of tranexamic acid combined with drainage effectiveness and safety of clamping 6 hour program of perioperative blood loss of primary total knee replacement patients. Methods 76 cases of unilateral total knee replacement in our hospital for the study. In the control group, Sodium Chloride Solution was injected into the joint cavity to keep the drainage tube open. The experimental group underwent intra-articular injection of tranexamic acid combined with drainage clamping 6 hour treatment. The total blood loss and complications of the experimental group and the control group were compared and analyzed. Results There were no serious adverse reactions in the experimental group and the control group, the incidence rate was 5.26% and 7.89% respectively, and there was no significant difference (P<0.05). The total blood loss in the experimental group was (526.78 ± 229.09) mL, significantly less than that in the control group, and the total blood loss was (879.03 ± 246.80) mL, with statistical difference (P<0.05). The postoperative blood loss in the control group was (489.08 ± 267.80) mL, and the postoperative blood loss in the experimental group was (287.90 ± 245.78) mL, the difference was statistically significant (P<0.05). On the 7 day after operation, the patients in the experimental group and the control group received venous color Doppler ultrasonography, but no venous thrombosis was found. Conclusion The intra-articular injection of tranexamic acid combined with drainage clamping 6 hour scheme in reducing the initial application of patients with single knee arthroplasty, the clinical effect is ideal, can significantly reduce blood loss, high safety, has clinical significance.