Study on association between MIC gene polymorphism and ureaplasma urealyt-icum infection / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1478-1482, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-657715
ABSTRACT
Objective:
To investigate the association between MIC allele polymorphism and susceptibility to Ureaplasma urealyticum infection.Methods:
PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of every one.Results:
Twelve allele genes of MICA and five MICA-STR and fourteen MICB were found in the participants,the frequency of MICA?010 and MICB?009N were higher in ureaplasma urealyticum infection patients than in healthy controls(MICA?010OR=3. 85,95%CI2. 12-6. 99, Pc<0. 05;MICB?009NOR=3. 22,95%CI1. 33-7. 80,Pc<0. 05);the frequencies of MICA-A5. 1 and MICB?00502 were lower in ureaplasma urealyticum infection patients than in healthy controls(MICA-A5. 1OR=0. 61,95%CI0. 40-0. 94,Pc<0. 05;MICB?00502OR=0. 58,95%CI0. 40-0. 83,Pc<0. 05),the differences were statistically significant;MICA?010/010,MICA?01201/01201 homozygote were higher in ureaplasma urealyticum infection patients than in healthy controls(MICA?010/010OR=14. 84, 95%CI1. 90-115. 9,Pc<0. 05MICA?01201/01201OR=10. 83,95%CI1. 35-86. 79,Pc<0. 05),the differences were statistically significant. The distribution frequency of MICB?00502/00502 in patients with ureaplasma urealyticum was higher,but the difference was not statistically significant(Pc>0. 05).Conclusion:
MIC allele gene polymorphism may be associated with ureaplasma urealyticum infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2017
Type:
Article
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