Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action
Journal of Menopausal Medicine
; : 62-64, 2016.
Article
in En
| WPRIM
| ID: wpr-65942
Responsible library:
WPRO
ABSTRACT
Menopause is a critical stage of women's life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms affecting about 50% to 80% of middle-aged women. Obviously, these symptoms, resulting from estrogen deficiency during menopause, can exert negative effects on women's health and quality of life and thus require to be managed through approaches such as hormone replacement therapy (HRT). Many herbal treatments for menopause symptoms contain and its components such as 8-prenylnaringenin, 6-PN, isoxanthohumol and xanthohumol. Recent in-vivo studies have highlighted the ability of 8-prenylnaringenin to reduce serum-luteinizing hormone (LH) and follicle-stimulating hormone (FSH), to increase serum prolactin levels and uterine weight, and to induce vaginal hyperplastic epithelium. Previous research has shown that hops extract can strongly bind to both estrogen receptors, stimulate alkaline phosphatase activity in Ishikawa cells, and upregulate presenelin-2 and progesterone receptor mRNA in Ishikawa cells. Numerous clinical trials have documented significant reductions in the frequency of hot flushes following the administration of hop-containing preparations. Nevertheless, further clinical trials with larger sample size and longer follow-up are warranted to confirm such benefits.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prolactin
/
Quality of Life
/
Sweat
/
Menopause
/
RNA, Messenger
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Follow-Up Studies
/
Women's Health
/
Sample Size
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Journal of Menopausal Medicine
Year:
2016
Type:
Article