Association of MTHFR C677T polymorphism with weight gain induced by risperidone in schizophrenia / 中华行为医学与脑科学杂志
Chinese Journal of Behavioral Medicine and Brain Science
; (12): 830-833, 2017.
Article
in Zh
| WPRIM
| ID: wpr-660423
Responsible library:
WPRO
ABSTRACT
Objective To explore the association of methylenetetrahydrofolate reductase (MTHFR)gene C677T polymorphism with weight gain induced by risperidone.Methods 356 patients with schizophrenia according to the DSM-IV criteria in this study.The height and body weight of the patients were measured before starting risperidone treatment and 8-week later.The MTHFRC677T polymorphism was genotyped using direct DNA sequencing method.Results A significant association was found between MTHFR gene C677T and body weight mass index (BMI) change after 8-week risperidone treatment.CC-carriers experienced higher BMI gain than CT/TT-carriers (CC (4.47 ± 1.09),CT (4.54 ± 1.27),TT (2.31 ± 0.75),F =5.634,P<0.01).The frequency of allele C in bodyweight gain (>7%) was higher than that in non-bodyweight gain groups (48.4% vs 32.4%,x2=11.342,P<0.01).Conclusion MTHFRC677T polymorphism is associated with risperidone induced weight gain in Chinese Han population.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Behavioral Medicine and Brain Science
Year:
2017
Type:
Article