Influence of gut microbiota on the development of tumor via the gut-brain axis / 中国肿瘤临床

ABSTRACT

Under normal circumstances, the gut microbiota and the proportion of symbiotic bacteria, probiotics, and pathogens re-main relatively stable, but dysbiosis in the gut can change not only the physiological environment of the intestine but also the physio-logical state of some distant tissues and organs. This condition can even lead to tumor development. Gut-brain axis is a pathway through which gut microbiota can influence tumor growth and is associated with other pathways, such as immune, metabolic, neuro-endocrine, and vagal neural pathways. This paper reports the relationship between tumor growth and microbial groups in the gut and the mechanisms of gut dysbiosis inducing a chronic stress state via the gut–brain axis, which affects tumor development. This paper also presents the role of gut microbiota in tumor treatment.